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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
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Articles 1 Documents
 1 
Search results for , issue "Vol 31 No 1, 2020 In Press" : 1 Documents clear
OPTIMIZATION OF FLOATING TABLET CONTAINING ASPIRIN USING SIMPLEX LATTICE DESIGN Siswanto, Agus
Indonesian Journal of Pharmacy Vol 31 No 1, 2020 In Press
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp%p

Abstract

Aspirin is an effective analgesic which is also used as an antiplatelet therapy for stroke prophylaxis. Aspirin in floating tablet formulations is used to improve the bioavailability. The aim of this study was to determine the optimum composition of floating tablets of aspirin by simplex lattice design (Design Expert 7.1.5). The tablets were prepared by direct compression technique, using polimers (Methocel K4M CR, Ethocel) and sodium bicarbonate (gas-generating agent) as independent variables. The optimum formula was determined based on numeric method with flow rate of tablet mass, floating lag time, C60, and Td as independent variables. The results indicated that the optimum composition of the matrix was Methocel K4M CR 16.94 %, NaHCO3 15.18 %, and Ethocel 17.88 %. It was observed that independent factors had significant contribution on all dependent variables.

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